Endurance is one of eight primary statistics . Its main use in to increase health and stamina, though it also increases hemorraging resistance. Each point put into Endurance raises health by 2, hemorraging resistance by .2 percent, and reduces stamina consumption by .16 percent.

In addition to being able to be raised with skill points, one cyber implants also increases endurance when upgraded. Adrenaline Pumper increases endurance by 1.5 for each level, to a maximum of a 15 point bonus.

Several weapons require a minimum endurance, most notable the Excidium assault cannon and the CAW Hammer rapid fire shotgun.